MRI Overestimates Excitotoxic Amygdala Lesion Damage in Rhesus Monkeys
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چکیده
منابع مشابه
MRI Overestimates Excitotoxic Amygdala Lesion Damage in Rhesus Monkeys
Selective, fiber-sparing excitotoxic lesions are a state-of-the-art tool for determining the causal contributions of different brain areas to behavior. For nonhuman primates especially, it is advantageous to keep subjects with high-quality lesions alive and contributing to science for many years. However, this requires the ability to estimate lesion extent accurately. Previous research has show...
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Earlier work indicated that combined but not separate removal of the amygdala and hippocampus, together with the cortex underlying these structures, leads to a severe impairment in visual recognition. More recent work, however, has shown that removal of the rhinal cortex, a region subjacent to the amygdala and rostral hippocampus, yields nearly the same impairment as the original removal. This ...
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Aspiration lesions of the amygdala were found previously to produce a severe impairment in visual discrimination learning for auditory secondary reinforcement in rhesus monkeys (Gaffan and Harrison, 1987). To determine whether excitotoxic amygdala lesions would also produce this effect, we trained four naive rhesus monkeys on the same task. The monkeys were required to learn 40 new visual discr...
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ژورنال
عنوان ژورنال: Frontiers in Integrative Neuroscience
سال: 2017
ISSN: 1662-5145
DOI: 10.3389/fnint.2017.00012